The Singapore Science Centre is the museum's planning consultant. It opened in 1977 and has been acclaimed as one of the top science centres in the world. Around a million people visit the Science Centre Singapore every year.

National Geographic Channel has signed an institutional partnership with The Mind Museum. This partnership will allow The Mind Museum to have complete access to National Geographic's extensive digital media library, which will be utilized in the museum's many multimedia-based exhibits.

The exhibition master plan and key exhibit designs have been undertaken by Jack Rouse Associates (JRA). Based in Cincinnati, USA, JRA was named as “one of the more prominent design firms by The Wall Street Journal. JRA specializes in the planning and design of science museums, theme park attractions, with clients including Science Centre Singapore, Kennedy Space Center, and the Natural History Museum of London.

Cobalt Engineering is the museum’s engineering consultant. Cobalt is a Canadian company with 20 years experience in mechanical and engineering services focusing on sustainable objectives and energy efficiency. It has 37 LEED (Leadership in Energy and Environmental Design) accredited professionals.

The building design is by renowned Filipino designer and architect, Lor Calma and Partners, Inc. (LC & P). LC & P was the designer of the awarded Philippine Pavilion in the World Expo in Aichi, Japan in 2005 and is the designer for the 2008 World Expo in Zaragoza, Spain.