Visitors will be welcomed by wide-open spaces prior to entering the five galleries. The Lobby, the Introductory Hall, the Ten Most Beautiful Experiments, and the Hall of Philippine Science all serve to initiate the visitors’ museum experience. The museum will offer the learning community venues for discussions, seminars, and workshops; these include the Theatre, the Mind Pods, and the Awesome Lab.

The 800 sqm Park will be the outdoor source of science fascination. Under the theme "Nature's Artful Play", the park will feature exhibits where visitors can learn science by enjoying and rediscovering anew, through play, the wonder of nature’s elements: sunlight, wind, water, and greenery. The park will include four main play pockets: Water, Math, Music, and Living Pockets. 

Each of the galleries will be connected by crucial links dubbed as Nature’s Webways. These will feature audio-visuals and exhibits that will help visitors make the transition in between the intricately woven stories of the galleries.

The Atom Gallery is the gallery with the most number of interactive exhibits. It will contain the very elemental forces that are so familiar that we take them for granted – gravity and electromagnetism. It will present the counterintuitive quantum world which resembles nothing in the ordinary, everyday experience, yet serves as the basis for much of the technology we find so common and take for granted – computers, mobile phones, lasers, and many medical technologies.

The Life Gallery is the gallery which feature’s the defining exhibit of the museum: The Human Brain. The gallery will feature the exuberance of a living planet in all its forms. It will feature the various habitats that nurture an astonishing number and kinds of organisms. This gallery will also feature the inner spaces that inhabit this life in the form of molecules called DNA.

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The Universe Gallery will showcase humankind’s wondrous fascination with outer space, and will include the mini-planetarium. It will feature exhibits that will show how all of life, as we know it now, found its atomic beginnings in the stars in space. It will enfold visitors in the fundamental elements and forces that are at play in the universe. It will also include wondrous images from the Hubble Space Telescope as well as a graphic history of humankind’s quest into other parts of the solar system.

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The Earth Gallery will feature the first T-REX exhibit in the country along with other unique exhibits that will focus on the earth and nature. Knowing natural history is the way we can educate museum visitors on how long it took the planet to give us what we now inhabit. The Earth Gallery will feature natural history from 4.6 billion years ago.

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At 680 sqm, this is the largest of all the galleries, and is the only exhibition space on the second level, overlooking the other four galleries. Its centrepiece, The Human Face of Technology – a 360° screen showing a constantly updated video of stories told by people about their favorite technologies and why they love them.

This gallery presents technology not as a mere tool, gadget, or industrial advancement but as means to flesh out human values, to help us become better humans. Thus, the gallery is divided into five major themes with each theme occupying a Node. The themes of the Nodes are: How We Live, Who We Are, How We Know, How Things Work, and Here to There.